Photoacoustic imaging is one of the most promising non-invasive biomedical imaging techniques. It combines laser light and ultrasound to generate high resolution 3D images (resolution 15–40 μm, 2 cm depth) of the tissue structure and molecular composition. The analyzed tissue is irradiated with pulsed laser light, which causes so-called thermoelastic expansion, which in turn generates mechanical w

https://www.photoacoustics.lu.se/platform/photoacoustic-imaging - 2025-07-25

Diffuse reflectance spectroscopy (DRS) utilizes white light with a known spectrum, which is guided to the surface of the skin via an optical fiber. As light penetrates into the tissue, photons either scatter or become absorbed where only a fraction of the injected photons manage to escape back from the skin surface. This light is captured by a second fiber and measured with a spectrometer. Dependi

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/commercial-diffuse-reflectance-spectroscopy - 2025-07-25

https://www.photoacoustics.lu.se/shortcuts - 2025-07-25

This project focuses on evaluating novel imaging techniques for measurement of perfusion and oxygenation in the anterior segment of the eye and the eye muscles during strabismus surgery. By doing this, the risk of anterior ischemia could be calculated and surgical techniques optimized. Left: Illustration of an eye and the four rectus muscles with the anterior ciliary arteries. Right: A LSCI image

https://www.photoacoustics.lu.se/clinical-applications/strabismus-surgery - 2025-07-25

Unsupervised skin tumour delineation using hyperspectral imaging and machine learning. Hyperspectral imaging provides detailed spectral and spatial information of a surface in ways our eyes are not capable of visualizing. We use a custom-made hyperspectral imaging camera from Norsk Elektro Optikk (NEO), capable of providing spectral information between 400-1700 nm. While this allows us to produce

https://www.photoacoustics.lu.se/technical-development/machine-learning - 2025-07-25

Lund University funding for research infrastructure (Lunds Universitetsgemensamma medel för forskningsinfrastuktur)Lund University has allocated funds for university-wide financing of infrastructure. These funds are announced annually by the university joint research committee. Interdisciplinary research environments with special strategic importance for the university are the focus of the call.Th

https://www.photoacoustics.lu.se/funding - 2025-07-25

We use the photoacoustic imaging technology platform to solve clinical problems while developing technology to make this possible. Motion Tracking Machine Learning Spectral Unmixing Spectral Coloring Tissue Heating

https://www.photoacoustics.lu.se/technical-development - 2025-07-25

Pediatric surgery for gastrointestinal and genital malformations The purpose of this project is to develop, evaluate and implement novel bioimaging techniques for monitoring perfusion and oxygenation during pediatric surgery, with regard to congenital anorectal malformations, Hirschsprung’s disease and tumors, and to assess the correlation to postoperative complications in the skin and intestine.

https://www.photoacoustics.lu.se/clinical-applications/pediatric-surgery - 2025-07-25

PhD thesis from the Lund University Photoacoustic Center. The thesis are opened in a new window.Hult J. Skin tumor delineation using photoacoustic imaging and hyperspectral imaging; Lund University; 2024-11-22Bunke J. Novel Bioimaging Techniques using Spectral Information for Monitoring Oxygen Saturation - Evaluated in Human Models of Skin Hypoperfusion; Lund University; 2024-10-11Naumovska M. Non

https://www.photoacoustics.lu.se/dissertations - 2025-07-25

We have a Teledyne FLIR A655sc camera for highly resolved thermal imaging, which allows for non-invasive temperature mapping of tissue. This enables direct feedback of the potentially damaging effects of absorbing too much laser light, which is important for setting guidelines for safe clinical implementation of PAI. Thermal imaging is also useful as a complementary monitoring system for a range o

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/thermography - 2025-07-25

Spectral coloring is a phenomenon that becomes relevant when studying light of different “colors” (wavelengths) propagating through tissue. It is expected that light gets attenuated as it reaches further into the tissue. However, since the absorbing species in the tissue interact with different wavelengths, the spectrum of light that remains to be absorbed at deeper layers will change shape and th

https://www.photoacoustics.lu.se/technical-development/spectral-coloring - 2025-07-25

Ultra-High frequency is the highest resolution of medical ultrasound available today. This groundbreaking technique opens up to new possibilities, for medical imaging, with resolution as fine as less than half a grain of sand.  Vevo® F2 With the VEVO® F2, FUJIFILM VisualSonics, is a unique and flexible system for research use, with the possibility of Ultra high to low frequency imaging (71–1 MHz).

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/ultrasound - 2025-07-25

The study of eye movements is an important source of information for researchers (eg neurobiologists, psychologists and optometrists) and healthcare professionals (eg neurologists, ophthalmologists, ear-nose-throat doctors, orthoptists). Research has shown that the study of eye movements is a powerful tool for understanding how our psyche and our brain work. Understanding all eye movement disorder

https://www.photoacoustics.lu.se/clinical-applications/gaze-tracking - 2025-07-25

The Lund University Clinical Center For Spectral and Acoustic Imaging is a unique interdisciplinary research infrastructure that relies on close ties between several faculties. The ecosystem depicted above demonstrates how the expertise of each partner plays an integral role in realizing the ultimate goal of improving clinical practices. Faculty of Medicine Department of OphthalmologyProf Malin Ma

https://www.photoacoustics.lu.se/organization - 2025-07-25

To discuss your ideas, please contact:DirectorProfessor Malin Malmsjö (medicine), Faculty of Medicine and Region Skåne, malin [dot] malsmjo [at] med [dot] lu [dot] se (malin[dot]malsmjo[at]med[dot]lu[dot]se), +46 (0) 722 335060Steering groupSenior Lecturer Magnus Cinthio (ultrasound), Lund Institute of Technology (LTH), magnus [dot] cinthio [at] bme [dot] lth [dot] se (magnus[dot]cinthio[at]bme[do

https://www.photoacoustics.lu.se/contact - 2025-07-25

Amyloidosis is a rare disease characterized by a buildup of abnormal amyloid deposits in the body. Amyloid deposits can build up in the heart, brain, kidneys, spleen and other parts of the body.  Amyloid in the heart reduces the ability to fill with blood between heartbeats. Less blood is pumped with each beat, and the patient experience shortness of breath. If amyloidosis affects your heart's ele

https://www.photoacoustics.lu.se/clinical-applications/amyloidosis - 2025-07-25

Ultrasonic contrast-free microvascular imaging using ultrafast Doppler is an emerging technology which has enabled microvascular imaging in brain, tumor vascularization imaging, and functional ultrasound. However, the technology has, as far as we know, mostly be used in situations with little or no motion artefacts and using clinical transducer frequencies. The rabbit pup brain is a very useful mo

https://www.photoacoustics.lu.se/clinical-applications/neonatal-cns-circulation - 2025-07-25

The goniometer employs the same light sources as the multispectral microscope, but has an extended capability to measure the scattering properties of a sample by determining the preferred angles light choses to scatter into. The goniometer is therefore important when characterizing the optical properties of human tissue, which in turn lays a foundation for proper interpretation of signals generate

https://www.photoacoustics.lu.se/welcome-photoacoustic-center/goniometry - 2025-07-25

Knowledge of how blood perfusion is affected during and after reconstructive surgery is of great importance to predict the survival of grafts and flaps. When commonly used reconstructive procedures were developed a century ago, they were based on empirical observations of clinical outcome. However, today modern, non-invasive techniques are available to monitor perfusion during and after surgery. A

https://www.photoacoustics.lu.se/clinical-applications/reconstructive-surgery - 2025-07-25

Malaria is responsible for over half a million deaths annually, however, these are primarily in the developing parts of the World. The reason why it remains a problem in only a few places is because the incidence is particularly high and the methods of diagnosing the parasitic illness are not efficient enough. Moreover, understanding the behaviour of the plasmodium parasite vector (the female  Ano

https://www.photoacoustics.lu.se/clinical-applications/malaria - 2025-07-25